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The role of EMT in ferroptosis. In epithelial cells, the intercellular contact portion inhibits ferroptosis through cadherin 1-mediated inhibition of YAP1 transcriptional activity. In contrast, cells in the mesenchymal state are susceptible to ferroptosis due to loss of intercellular contact and activation of factors involved in epithelial to mesenchymal transition (EMT), such as ZEB1, SNAI1, and Twist1.
