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The link between cancer and immunity. Immune cells regulate the ferroptosis sensitivity of cancer cells on the one hand. CD8+T cells and macrophages affect the expression of ferroptosis-related genes in cancer cells by secreting INFγ and TGFβ1, respectively, sensitizing ferroptosis. On the other hand, DAMPs released from iron-dead cells result in M2 polarization of macrophages, leading to immune remodeling.
