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. 2021 Nov 15;11(11):5249–5262.

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AGR2 expression in the gastrointestinal tract of the human embryo. The human embryonic and fetal material from 3 to 20 weeks of development was obtained from the MRC-Welcome Trust Development Human Developmental Biology Resource (HDBR) tissue bank. Two sections of the human embryo and fetal tissues were used for each stage from Carnegie Stage 19 (CS) of embryonic development up to post-conception week 14 (PCW14). The AGR2 antibody was optimized for Formalin-Fixed Paraffin-Embedded (FFPE) tissues. The immunostaining was performed, and the pictures were scanned using Panoramic 250 3D Histech. AGR2 was found to be expressed across the gastrointestinal tract in several stages of embryonic development: in esophagus and trachea in CS19 (A, B); in the junction of esophagus and stomach; in CS20 (C, D), herniated intestines, stomach, duodenum, and pylorus in CS23 (E-H); and rectum and urethra in PCW10 (I-K).

Figure 1.