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. 2021 Nov;9(21):1618. doi: 10.21037/atm-21-2620

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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miR-155 upregulation in monocytes of chronically HCV-infected individuals. (A) Representative dot plots of flow cytometric analysis for CD14⁺ monocytes in PBMCs, stained with isotype and CD14-FITC antibodies, >90% CD14⁺ monocytes were isolated from PBMCs. (B) CD14⁺ monocytes were purified from PBMCs of 12 healthy controls, 12 HCV-infected patients and 12 HCV-infected patients who achieved sustained virological response (SVR), after which miR-155 levels were examined by real-time RT-PCR. miR-155 fold-change (2^−∆∆Ct) from HCV-infected patients was normalized to that of healthy controls. (C-E) Monocytic THP-1 cells were stimulated with or without LPS, HCV core, or HCV NS5 for 6 h, followed by real-time RT-PCR analysis of miR-155 levels (n=6, repeated three times).