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. 2021 Nov 16;12(23):4406–4415. doi: 10.1021/acschemneuro.1c00454

Table 1. Fitted Rate Constantsa.

  tau304–380_C322S Aβ42
k+kn <10–2 M–1 s–2b 900 M–2 s–2
k+k2 6 × 1011 M–3 s–2 4 × 1010 M–3 s–2
KM 30 nM >6 μM
a

The products of rate constants for tau304-380_C322S and in 20 mM sodium phosphate, 0.2 mM EDTA, pH 8.0. Data for Aβ42 from ref (6) are included for comparison.

b

Value ill determined; only an upper limit could be determined based on the data. Best fit obtained with nc = 1.