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. 2021 Nov 26;13(11):1625–1646. doi: 10.4252/wjsc.v13.i11.1625

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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Overview of the functional improvements of mesenchymal stromal cell (MSC) properties by priming strategies. MSCs can be primed via different approaches, such as priming culture conditions, pretreatment with mechanical and physical stimuli, preconditioning with cytokines and growth factors, and genetic modification. As promising outcome, primed MSCs can exhibit prolonged therapeutic efficacy, including migration, anti-apoptosis, anti-inflammation, immunomodulation, proangiogenesis, and regenerative properties. The improved capabilities are interconnected and greatly influenced by priming approaches.