TABLE 3.
Summary of secondary outcomes of included studies
| Survival | Migration | Differentiation a | Neuroinflammation | |||
|---|---|---|---|---|---|---|
| Study | Last time point cells detected b | Evidence of cell migration? | Neuron | Astrocyte | Oligodendrocyte | Effect on inflammation |
| Braccioli 2017 28 | 5 d | Yes | ✓ Doublecortin | × GFAP | — | Anti‐inflamatory (Iba‐1) |
| Braccioli 2017 29 | 5 d | — | ✓ Doublecortin | — | — | — |
| Chau 2014 30 | 7 d | — | ✓ NeuN, neurofilament | ✓ GFAP | — | — |
| Comi 2008 31 | 26 d | — | ✓ Morphology | — | — | — |
| Daadi 2010 32 | 28 d | — | ✓ NeuN, TuJ1+, doublecortin, GAD | ✓ GFAP | — | Pro‐inflammatory (Iba‐1) |
| Ji 2015 33 | 42 d | Yes | ✓ NeuN | ✓ GFAP | — | Anti‐inflammatory (IL‐1) |
| Kim 2018 34 | 35 d | — | NA c | NA c | ✓ Olig2, MBP | — |
| Li 2015 35 | 28 d | — | ✓ NSE | — | — | — |
| Rumajogee 2018 36 | 133 d | Yes | ✓ NeuN, doublecortin | ✓ GFAP | ✓ Olig2 | — |
| Sato 2008 37 | 7 d | Yes | ✓ MAP‐2 | — | — | — |
| Shin 2018 38 | 84 d | — | ✓ Neurofilament | ✓ GFAP | — | Anti‐inflammatory (Iba‐1) |
| Shinoyama 2013 39 | 21 d | Yes | ✓ NeuN, Ctip2 | — | — | — |
| Tan 2014 40 | — | — | — | — | — | — |
| Titomanlio 2011 41 | 37 d | Yes | ✓ MAP2, NeuN | × GFAP | ✓ NG2, MBP | — |
| Wang 2014 42 | 28 d | — | ✓ NeuN | ✓ GFAP | ✓ CNPase | — |
| Yao 2016 43 | — | — | — | — | — | — |
| Ye 2018 44 | — | Yes | ✓ NeuN | ✓ GFAP | — | — |
| Zheng 2012 45 | — | — | — | — | — | — |
Note: (—) = not assessed, ✓ = yes, x = no differentiation
Abbreviations: CNPase, 2′,3′‐cyclic‐nucleotide 3′‐phosphodiesterase; Ctip2, chicken ovalbumin upstream promotor transcription factor 2; GAD, glutamic acid decarboxylase; GFAP glial fibrillary acidic protein; Iba‐1, ionized calcium binding adaptor protein 1; IL‐1β, interleukin 1 beta; Inflam, inflammatory; MAP‐2, microtubule‐associated protein 2; MBP, myelin basic protein; NA, not applicable; NeuN, neuronal nuclei; NG2, nerve/glial antigen 2; NSE, neuron‐specific enolase; Olig2, oligodendrocyte transcription factor 2; TuJ1+, neuron‐specific class III ‐tubulin.
Differentitation markers.
Time point post NSC administration.
This study used an oligodendrocyte progenitor cell, and therefore we would not expect this cell type to differentiate into neurons or astrocytes.