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. 2021 Dec 2;138(22):2185–2201. doi: 10.1182/blood.2021012037

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© 2021 by The American Society of Hematology

This article is made available via the PMC Open Access Subset for unrestricted reuse and analyses in any form or by any means with acknowledgment of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 2. — Mapping of the tested FH variants. FH N-terminal (A) and C-terminal (B) crystal structure. The surfaces that interact with C3b (N terminus) and C3d (C terminus) are depicted in yellow. The FI-interacting surface in the N terminus and the sialic acid binding site in the C terminus are depicted in purple. The position of all variants is indicated in orange. FH variant classification codes are based on functional assay results: benign (green), nonexpressed (black), and functionally impaired (red).