Table 1.

Linear Mixed-effects models (LMM). The LMM shows the intraclass correlation coefficient (ICC), the effects of age at the time of vaccination, and the follow-up time effect on the vaccine-induced anti-CSP IgG responses for 7 years

Predictors	RTS,S/AS01-induced anti-CSP IgG Abs		RTS,S/AS01-induced anti-CSP IgM Abs		Naturally-induced anti-CSP IgM Abs (control group)
	Coef. (95% CI)	P-value	Coef. (95% CI)	P-value	Coef. (95% CI)	P-value
Time in years (follow-up)	− 0.040 (− 0.051, − 0.043)	< 0.001	0.004 (0.002, 0.006)	< 0.001	0.021 (0.010, 0.020)	< 0.001
Age (5–17 months) at the time of vaccination	− 0.021 (− 0.110, 0.062)	0.602	0.028 (− 0.010, 0.064)	0.143	0.024 (− 0.031, 0.073)	0.47
ICC (δ)	0.28 (3.69)		0.28 (0.68)		0.23 (1.63)

ICC, intraclass correlation coefficient, δ, random effect variances