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. 2021 Dec 3;8:62. doi: 10.1186/s40779-021-00356-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — LMP2 inhibition increased the levels of tight junction proteins, improved BBB integrity and upregulated Wnt/β-catenin signalling after MCAO. a Western blotting showed the levels of tight junction proteins occludin, claudin-1, ZO-1 proteins in each group rats. b Immunofluorescence staining and quantitative analysis of CD31 in brain cortex tissue from each group rats. c FITC-dextran angiographic micrographs and quantitative analysis of FITC in brain cortex tissue from each group rats. d Representative Western blotting images of Wnt-3a and β-catenin proteins in brain cortex tissue from each group rats. Data are presented as the mean ± standard deviation (SD) from three independent experiments (each group rats n = 4). *P < 0.001, compared with the sham group; ^#P < 0.001, compared with the control-shRNA group. All scale bars = 50 µm