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. 2021 Dec 3;8:62. doi: 10.1186/s40779-021-00356-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Silencing LMP2 reversed the downregulated expression of the occludin, claudin-1 and ZO-1 proteins in RBMVECs following OGD/R. a Transfection efficiency of LMP2-siRNA was verified by RT-PCR and Western blotting. *P < 0.001, compared with the Si1 group, ^#P < 0.001, compared with the Si2 group. ^&P < 0.001, compared with the NC group. b Western blotting showed that the levels of occludin, claudin-1 and ZO-1 proteins in RBMVECs in each group. Data are presented as the mean ± standard deviation (SD) from three independent experiments. *P < 0.001, compared with the normal group; ^#P < 0.001, compared with the control-siRNA group. OGD/R oxygen–glucose deprivation and reoxygenation; NC group negative control group; RBMVECs rat brain microvascular endothelial cells