Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model of 53BP2 pathways. In undamaged cells, p53 mediates the suppression of 53BP2 levels. UV damage can relieve this suppression and increase 53BP2 levels. Through unknown mechanisms, 53BP2 can inhibit cell growth and promote damage-induced apoptosis after UV irradiation, as well as enhance p53 transactivation and cell cycle arrest. Lines with arrowheads denote positive regulation; the slashed line denotes negative regulation. “p53*” denotes the DNA damage-activated state.
