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. 2021 Dec 2;21:602. doi: 10.1186/s12888-021-03516-4

Table 2.

Neuropsychological tests by diagnostic groups

FEPa (n = 119) CHR-Pb (n = 54) CHR-Nc (n = 46) All (n = 219) FEP/CHR-P FEP/CHR-N CHR-P/CHR-N
Mean SD Mean SD Mean SD Mean SD p1 p2 p3 p4
Verbal skills
 WAIS III Vocabulary 42.61 10.84 42.80 10.57 43.07 10.85 50.14 7.54 0.970 0.914 0.806 0.901
 MCCB Category Fluency 22.23 5.71 22.98 5.24 24.52 7.39 24.36 6.12 0.090 0.444 0.029 0.202
 MCCB S-words 15.11 5.56 15.54 5.48 16.83 4.45 16.51 5.40 0.180 0.625 0.065 0.229
Attention/vigilance
 TMT-A 32.94 10.18 28.17 8.33 31.52 10.93 29.70 9.83 0.015 0.004 0.411 0.093
 TMT-B 92.18 66.00 86.24 82.34 66.50 38.08 75.81 58.28 0.082 0.583 0.026 0.137
Speed of processing
 WAIS III Digit Symbol 66.37 15.78 73.44 16.85 74.59 15.54 75.24 16.97 0.002 0.008 0.003 0.722
Working memory
 WAIS III Letter-Number Span 9.97 2.22 10.59 2.02 11.17 2.34 10.94 2.38 0.006 0.088 0.002 0.189
 WMS-R Spatial Span 16.87 3.01 17.57 2.95 17.22 2.15 17.63 2.88 0.313 0.126 0.477 0.523
Verbal learning
 HVLT immediate 25.94 4.29 27.31 4.60 28.89 3.95 27.79 4.43 < 0.001 0.053 < 0.001 0.069
 HVLT delayed 9.18 2.12 10.19 1.90 10.35 1.72 10.04 1.95 < 0.001 0.002 0.001 0.684
Visual learning
 MCCB BVMT-R 24.37 6.98 26.96 6.43 26.65 6.51 26.87 6.59 0.029 0.020 0.053 0.819
Reasoning and problem solving
 MCCB NAB Mazes 20.43 4.89 22.07 3.59 22.24 4.15 21.78 4.18 0.018 0.025 0.020 0.854
WCST
 Total number of errors 30.20 24.54 28.24 19.23 22.35 18.18 28.07 22.22 0.125 0.589 0.042 0.185
 Perseverative responses 18.73 19.06 16.63 12.98 12.91 11.21 16.99 16.39 0.122 0.433 0.041 0.257
 Perseverative errors 16.36 15.00 15.11 10.91 11.87 9.47 15.11 13.12 0.143 0.560 0.049 0.218
 Percent conceptual level responses 64.51 21.74 66.07 16.94 71.46 17.17 66.36 19.84 0.130 0.630 0.044 0.176
 Number of categories completed 4.96 1.68 5.11 1.42 5.39 1.31 5.09 1.55 0.272 0.547 0.108 0.368
Ro-Exner (RCS)
 Perceptual thinking index (PTI) 1.25 1.34 1.37 1.19 0.70 1.07 1.16 1.27 0.016 0.566 0.011 0.008
 Distorted perception (X-%) 0.28 0.11 0.28 0.09 0.21 0.08 0.26 0.10 0.001 0.824 0.001 0.002
 Incoherent thinking (WSum6) 9.90 8.70 9.69 7.56 7.02 6.50 9.24 8.06 0.108 0.871 0.040 0.099
 Appropriate answers (XA%) 0.70 0.12 0.70 0.09 0.76 0.09 0.71 0.11 0.002 0.923 0.001 0.003
 Extended appropriate answers (WDA%) 0.73 0.12 0.73 0.09 0.79 0.08 0.75 0.11 0.003 0.902 0.001 0.005

aFirst episode psychosis

bConfirmed clinical high risk to psychosis

cNonconfirmed clinical high risk to psychosis; p1 = ANOVA for all patients; p2 = ANOVA for FEP/CHR-P; p3 = ANOVA for FEP/CHR-N; p4 = ANOVA for CHR-P/CHR-N