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editorial

. 2021 Dec 3;22:325. doi: 10.1186/s13059-021-02550-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Partial phylogeny of eukaryotes. The genomes of plants, animals, and fungi contain the epigenetic mark H3K9me3 (the lysine residue at position 9 of histone H3 can be tri-methylated). H3K9me3 is thus present in the clades Archaeplastida and Opisthokonta, which have a common ancestor close to the base of all eukaryotes. This suggests that H3K9me3 was already present in early eukaryotes, around the time when retrotransposons appeared in their genomes (phylogeny adapted from [6], showing only the clades that are relevant for the argument)