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. 2021 Oct 14;218(12):e20211327. doi: 10.1084/jem.20211327

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© 2021 Lu et al.

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Figure 5. — Cross-reactivity of SARS-CoV-2–specific public Tfh clonotypes. (A) Alignment of corresponding peptides. Amino acids identical to SARS-CoV-2 epitopes are shown in black. (B) Cells expressing clonotype 5 (TCR-017 or TCR-018) were stimulated with 1 μg/ml of peptides derived from the MATE family efflux transporter of S. noxia. (C) Cells expressing the TCR from clonotype 2 were stimulated with 1 μg/ml of peptides derived from K. pneumoniae yersiniabactin ABC transporter ATP-binding/permease protein (YbtP) or Bacteroidales bacterium TonB-dependent receptor (TBDR). Accession numbers of TBDRs from different Bacteroidales bacteria in GenBank are shown. (D) Cells expressing TCRs from clonotype 5 (TCR-017) or clonotype 2 were stimulated with heat-killed E. coli transformed with expression vectors for the indicated microbial proteins in the presence of monocyte-derived dendritic cells (Mo-DCs) expressing DRB1*15:01. Data are representative of two independent experiments (B–D).