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. Author manuscript; available in PMC: 2022 May 14.
Published in final edited form as: ACS Infect Dis. 2020 Oct 31;7(5):1089–1103. doi: 10.1021/acsinfecdis.0c00508

Scheme 2. Reagents and reaction conditions:

Scheme 2.

(a) (i) tributylamine, 180 °C, 1 h; (ii) phosphorus oxychloride, 110 °C, 16 h, 26–44% over two steps; (b) appropriate amine, DMF, rt to 90 °C, 1–72 h, 15–100%; (c) 26 or 32, sodium acetate, Pd/C, H2, MeOH, 20–48 h, 22–49%.