Table 1.

Phenotypic alterations expressed as descriptors and their associated severity score color for S. mansoni somules and adults upon exposure to MT-active agents.

		Somules (1 μM)a		Somules (10 μM)a		Adults (5 μM)a
Cpd#	Structure	24 h	48 h	24 h	48 h	5 h	24 h	48 h
1		N	N	Dark	R, deg	N	Unc	N
2		N	N	Unc	R, deg	N	N	N
3		N	N	N	R, dark	N	N	N
4		N	N	N	N	S	N	N
5		N	N	N	N	N	Unc	Unc
6		N	N	N	N	N	N	Unc
7		N	Dark	R, deg	R, deg	Unc, on sides	Dark, unc, on sides	Dark, unc, on sides
8		N	Dark	R, deg	R, deg	Unc, on sides	Unc, on sides	Dark, unc, on sides
9		N	N	R, deg	R, deg	Unc, on sides, slight shrunk	Unc, on sides, slight shrunk	Dark, unc, on sides
10		N	N	Unc	R, deg	Unc, on sides	Unc, on sides	Unc, on sides
11		R, unc	N	R, deg	R, deg	N	N	Unc, on sides
12		R, deg	R, deg	R, deg	R, deg	N	Dark, unc, slight shrunk	S, on sides, slight shrunk
13		R, dark	R, deg	R, deg,	R, deg	N	Unc	N
14		Dark	R, deg	R, deg	R, deg	Unc	Dark, unc	Dark, unc, on sides
15		Deg	Deg	Deg	Deg	Dark, unc	Dark, unc	Unc
16		R, deg	R, deg	R, deg,	D	N	S, on sides, slight shrunk	S, on sides
17		R, deg	R, deg	R, deg	R, deg	N	N	Slight shrunk
18		R, deg	R, deg	R, deg	R, deg	S	S, slight shrunk	Slight shrunk
19		R, deg	R, deg	R, deg	R, deg	N	S, slight shrunk	S, slight shrunk
20		R, deg	R, deg	R, deg	R, deg	Deg, S	Deg, on sides	Deg, on sides
PZQ		Unc	Unc	Deg	Deg	Deg	D	D
DMSO		N	N	N	N	N	N	N

^aThe descriptors and their respective abbreviations are: normal (N); round (R); on sides (adult male worms unable to use oral and/or ventral sucker to adhere to the floor of the well); uncoordinated movements (unc); shrunk (adult worms are not flexing and are smaller than usual); dark; slow (S); immobile (I); degenerate (deg); damage to the surface tegument (teg dam); dead (D). Each descriptor is given a value of 1, except for deg and teg dam which are given the maximum value of 4 and I which is given a value of 2. Data are from a minimum of two experiments each in duplicate and representative data are shown.