Table 1.
The demographic and clinical characteristics and laboratory findings of scrub typhus patients
| Characteristics | Scrub typhus (N = 63) |
|---|---|
| Age, y; mean ± SD | 67.6 ± 12.6 |
| Gender, n (%) | |
| Male | 19 (30.2) |
| Female | 44 (69.8) |
| Comorbidities, n (%) | |
| Cardiovascular disease* | 11 (17.5) |
| Cerebrovascular disease | 13 (20.6) |
| Pulmonary disease† | 3 (4.8) |
| Connective tissue disease | 0 (0.0) |
| Liver disease | 2 (3.2) |
| Chronic kidney disease | 0 (0.0) |
| Diabetes mellitus | 23 (36.5) |
| Solid tumor | 5 (7.9) |
| Clinical signs and symptoms, n (%) | |
| Headache | 30 (47.6) |
| Dyspepsia | 30 (47.6) |
| Nausea/vomiting | 19 (30.2) |
| Abdominal pain | 13 (20.6) |
| Fever | 63 (100.0) |
| Myalgia | 35 (55.6) |
| Lymphadenopathy | 21 (33.3) |
| Rash | 44 (69.8) |
| Eschar | 55 (87.3) |
| Laboratory values, median (IQR) | |
| WBC count, ×1,000/mm3 | 7.9 (5.8–10.7) |
| Platelet count, ×1,000/mm3 | 128.0 (101.3–174.5) |
| Total bilirubin, mg/dL | 0.7 (0.5–0.9) |
| Albumin, g/dL | 3.5 (3.0–3.9) |
| AST, IU/L | 88.0 (54.3–148.5) |
| ALT, IU/L | 74.0 (39.0–115.3) |
| Lactate dehydrogenase | 859.5 (687.0–986.0) |
| Creatinine, mg/dL | 0.8 (0.6–1.1) |
| hs-CRP, mg/dL | 104.3 (62.5–161.1) |
| Genotype, n (%); N = 61 | |
| Boryong strain | 50 (82.0) |
| Karp strain | 9 (14.8) |
| Gilliam strain | 1 (1.6) |
| Kawasaki strain | 1 (1.6) |
| Treatment, n (%) | |
| Doxycycline | 56 (88.9) |
| Azithromycin | 4 (6.3) |
| Azithromycin or doxycycline | 3 (4.8) |
ALT = alanine aminotransferase; AST = aspartate aminotransferase; hs-CRP = high-sensitivity C-reactive protein; IQR = interquartile range; WBC = white blood cell.
*Includes myocardial infarction, congestive heart failure, and peripheral vascular disease.
†
Includes chronic obstructive pulmonary disease and asthma.