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The role of remimazolam in inflammatory. LPS induces macrophage secretion of cytokines, such as TNF-α, IL-6, and IL-1β, which could directly lead to inflammatory response. As a result, remimazolam not only had effect on the activation of NF-κB, p38MAPK, ERK1/2, and PI3K signal pathway at 15 min after LPS treatment but also regulate Rab5a related TLR4 expression at cell surface in response to LPS at later time.
