Table 1.
Agonists and antagonist S1R
| Agonist | Antagonist |
|---|---|
| Fluoxetine | Haloperidol |
| Fluvoxamine | E-5842 (4-(4-fluorophenyl)-1,2,3,6-tetrahydro-1-[4-(1,2,4-triazol-1-il)bu tyl]pyridine citrate) |
| Sertraline | BMY-14802 |
| Escitalopram | Piperazine |
| Citalopram | Rimcazole (BW234U) |
| Donepezil | BD-1047 (N-(2-(3,4-dichlorophenyl)-N-methyl-2-(dimethylamino)ethylamine) |
| Ifenprodil | BD 1063 (1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine) |
| Dehydroepiandrosterone (DHEA) | DuP734 (1-(cyclopropylmethyl)-4-(2′-(4″-fluorophenyl)-2′- oxoethyl)-piperidine HBr) |
| Pregnenolon | Progesterone |
| Igmesine (JO-1784) | RC106 |
| Amitriptyline | NPC-16377 (6-[6-(4-Hydroxypiperidinyl)hexyloxy]-3-methylflavone HCI) |
| Memantine | Panamesine |
| PRE-084 (2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate) | NE-100 (4-Methoxy-3-(2-phenylethoxy)- N,N-dipropylbenzeneethaneamine) |
| ( +)-Pentazocine | Verapamil |
| Dextromethorphan | Phenylpropyloxyethelene |
| ( +)-SKF 10,047 (( +)-N-allylnormetazocine) | MS-377 ((R)-( +)-1-(4-chlorophenyl)-3-[4-(2-methoxyethyl)piperazin-1-yl]methyl-2-pyrrolidinone l-tartrate) |
| PPBP (4-phenyl-1-(4-phenylbutyl)piperidine) | BD-1008 (N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine) |
| 3-PPP (N-n-propyl-3-(3-hydroxyphenyl)piperidine) | BD-1063 (1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine) |
| AF710B (1-(2,8-Dimethyl-1-thia-3,8-diazaspiro(4,5)dec-3-yl)-3-(1H-indol-3-yl)propan-1-one) | BD-1067 (N-[2-(3,4-dichlorophenyl)ethyl]-N-ethyl-1-pyrrolidineethanamine) |
| BD-737 | LR-132 (( +)-3,4-dichloro-N-[(1R,2S)-2-(1-pyrrolidinyl)cyclohexyl]benzeneethanamine) |
| OPC-14523 | LR-172 (N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-homopiperidinyl)eth ylamine) |
| SA 4503, cutamesine (1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl) piperazine) | UMB-101 |
| DMT (N,N-dimethyltryptamine) | YZ-069 (N-phenylpropyl-N′-(3,4-dichlorophenethyl)piperazine0 |
| DTG (1,3-di-o-tolylguanidyne | YZ-185 (N-Phenylpropyl-N′-(3-methoxyphenethyl)piperazine) |
| BD-1031 (1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine) | MR309 (E-52862) |
| BD-1052 (N-[2-(3,4-dichlorophenyl)ethyl]-N-2-propen-1-yl-1-pyrrolidineethanamine) | AC-927 (1-(2-phenylethyl)piperidine) |
| Dimemorfan | |
| Pridopidine | |
| Pentoxyverin | |
| Methamphetamine | |
| MDMA (3,4-methylenedioxymethamphetamine) | |
| Cocaine | |
| ANAVEX2-73 (blarcamesine) | |
| Edonerpic |