Table XXXV.

Agents used in treatment of lipid disorders in children and adolescents available in Poland

Agent name(s)	Doses initial maximum	Possible adverse effects	Contraindications in children
Statins: Simvastatin Atorvastatin Rosuvastatin Pravastatin	5–40 mg 5–40 mg 5–20 mg 5–20 mg before 13 years of age 40 mg before 18 years of age	Elevated hepatic aminotransferases, myalgia, myopathy, rhabdomyolysis (very rare), gastrointestinal disorders, fatigue, insomnia, headache, skin lesions, peripheral neuropathy, lupus-like syndrome	Drug hypersensitivity, myopathy due to statin administration, active liver disease, high activity of aminotransferases or 3 times the upper limit of normal range during statin administration, renal failure, severe infections, serious trauma and surgery, severe metabolic disorders, hormonal, uncontrolled epileptic seizures
Inhibitor of cholesterol absorption: Ezetimibe	10 mg	Myalgia, myopathy, fatigue, headache, abdominal pain, diarrhoea, flatulence, dyspepsia, gastroesophageal reflux disease, nausea, elevated aminotransferase activity	Drug hypersensitivity, impaired hepatic function, high aminotransferase activity