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. 2021 Nov 19;27:1609997. doi: 10.3389/pore.2021.1609997

FIGURE 2.

FIGURE 2

Ets1 upregulation in glioblastoma endothelial cells depend on TGFβ signaling. (A) RNA levels of Ets1 in bEND.3 cells treated with VEGFA, TNFα or TGFβ (mean + SD of four independent experiments; **p < 0.01; ANOVA with Tukey’s multiple comparisons test). (B) RNA levels of Ets1 in bEND.3 cells treated with conditioned medium from CT-2A glioma cells with TGFβ neutralizing antibody or control antibody (mean + SD of four independent experiments; **p < 0.01; One-way ANOVA with Tukey’s multiple comparisons test). (C) Immunohistochemical staining and quantification of Ets1 in CT-2A glioma tumor-bearing mice treated with/without galunisertib (bar: 50 μm) (n = 10/group, Mann-Whitney test, *p < 0.05).