TABLE 1.

Mendelian randomization association of genetically determined sedentary behaviors with cerebrovascular disease traits and neurodegenerative disease traits.

Outcome	Television watching					Computer use
	OR/beta (95%CI)	p value	I 2	P Q	P intercept	OR/beta (95%CI)	p value	I 2	P Q	P intercept
Cerebrovascular disease traits
AS	1.32(1.15,1.52)	1.1E-04	37.3	<0.001	0.14	0.88(0.71,1.10)	0.27	19.6	0.13	0.66
AIS	1.28(1.10,1.49)	1.2E-03	35.4	0.002	0.20	0.94(0.74,1.19)	0.62	19.1	0.13	0.56
CES	0.99(0.78,1.25)	0.92	24.1	0.003	0.44	1.30(0.82,2.06)	0.26	21.9	0.10	0.23
LAS	1.48(1.09,1.99)	0.01	20.1	0.01	0.12	0.84(0.48,1.48)	0.55	11.2	0.26	0.44
SVS	1.66(1.21,2.27)	1.8E-03	27.2	0.003	0.89	0.73(0.44,1.20)	0.22	4.8	0.38	0.46
ICH	1.97(1.03,3.75)	0.04	0	0.52	0.80	0.26(0.08,0.86)	0.03	0	0.99	0.75
Non-lobar ICH	1.61(0.75,3.49)	0.22	0	0.95	0.61	0.16(0.04,0.67)	0.01	0	0.99	0.84
Lobar ICH	2.25(0.93,5.40)	0.07	8.6	0.18	0.61	0.45(0.08,2.37)	0.35	0	0.79	0.42
WMH	0.12(−0.02,0.27)	0.10	12.4	0.09	0.91	0.29(−0.06,0.64)	0.10	43.8	0.001	0.44
Neurodegenerative disease traits
AD	1.15(0.97,1.36)	0.11	16.6	0.03	0.06	0.67(0.48,0.92)	0.01	14.2	0.21	0.99
PD	0.65(0.50,0.84)	1.3E-03	18.5	0.04	0.13	0.98(0.62,1.55)	0.92	12.0	0.24	0.06
MS	1.00(0.99,1.00)	0.84	33.6	0.02	0.72	1.00(1.00,1.01)	0.90	33.9	0.01	0.78
CP	−0.46(−0.55,−0.37)	1.2E-24	84.8	<0.001	0.28	0.65(0.50,0.80)	4.0E-17	82.5	<0.001	0.14

beta, the Mendelian randomization effect of continuous variable outcome, such as white matter hyperintensity and cognitive performance.

OR, odds ratio; CI, confidence interval; P_Q, p value corresponding to Cochran Q test; P_intercept, p value corresponding to MR-Egger intercept test; AS, all-cause stroke; AIS, all-cause ischemic stroke; CES, cardioembolic stroke; LAS, large-artery atherosclerotic stroke; SVS, small vessel stroke; ICH, intracerebral hemorrhage; WMH, white matter hyperintensity; AD, Alzheimer’s disease; PD, Parkinson’s disease; MS, multiple sclerosis; CP, cognitive performance. Bold value indicates a p value of < 1.3 × 10⁻³.