TABLE 2.

Multivariable Mendelian randomization of genetically determined television watching and stroke adjusted for confounding traits.

	All-cause stroke		Any ischemic stroke
	OR (95%CI)	p value	OR (95%CI)	p value
Adjusted for blood pressure traits
Systolic blood pressure	1.31 (1.15, 1.49)	3.2E-05	1.27 (1.12, 1.46)	3.5E-04
Diastolic blood pressure	1.29 (1.14, 1.47)	6.8E-05	1.26 (1.10, 1.44)	6.7E-04
Pulse pressure	1.33 (1.18, 1.51)	6.5E-06	1.30 (1.14, 1.48)	8.3E-05
Adjusted for serum lipid traits
HDL-cholesterol	1.39 (1.15, 1.69)	8.8E-04	1.37 (1.12, 1.67)	2.0E-03
LDL-cholesterol	1.37 (1.15, 1.63)	3.9E-04	1.33 (1.11, 1.59)	1.6E-03
Total cholesterol	1.37 (1.15, 1.62)	3.7E-04	1.34 (1.12, 1.59)	1.3E-03
Triglyceride	1.35 (1.12, 1.63)	1.8E-03	1.32 (1.09, 1.60)	5.1E-03
Adjusted for glycemic traits
Fasting glucose	1.35 (1.12, 1.62)	1.5E-03	1.33 (1.10, 1.61)	3.8E-03
Fasting insulin	1.40 (1.16, 1.69)	3.9E-04	1.36 (1.12, 1.65)	2.2E-03
HOMA-B	1.43 (1.20, 1.70)	6.2E-05	1.39 (1.16, 1.66)	4.3E-04
HOMA-IR	1.41 (1.16, 1.71)	6.0E-04	1.36 (1.11, 1.66)	3.1E-03
HbA1c	1.36 (1.14, 1.62)	5.2E-04	1.34 (1.12, 1.61)	1.4E-03
Insulin sensitivity index	1.35 (1.14, 1.60)	6.4E-04	1.33 (1.11, 1.59)	1.6E-03
Adjusted for obesity traits
Body mass index	1.29 (1.10, 1.52)	2.0E-03	1.28 (1.08, 1.52)	4.1E-03
Waist-to-hip ratio	1.30 (1.10, 1.54)	1.7E-03	1.29 (1.08, 1.53)	4.4E-03
Adjusted for lifestyle traits
Smoking	1.31 (1.15, 1.49)	6.9E-05	1.27 (1.10, 1.46)	8.1E-04
Alcohol use	1.33 (1.17, 1.51)	1.5E-05	1.28 (1.12, 1.47)	2.6E-04
Physical activity	1.39 (1.23, 1.57)	1.4E-07	1.36 (1.20, 1.54)	2.3E-06

HOMA-B, homeostatic model assessment of β-cell function; HOMA-IR, homeostatic model assessment of insulin resistance; HDL-cholesterol, high-density lipoprotein cholesterol; LDL-cholesterol, low-density lipoprotein cholesterol; OR, odds ratio; CI, confidence interval.