Table 2.
Univariable analysis of characteristics between L-GrAFT7 high and low risk group.
| Variables | Frequency (%) or Median (IQR) | P-value | |
|---|---|---|---|
| High-risk group | Low-risk group | ||
| N = 150 | N = 527 | ||
| Recipient | |||
| Age (years) | 51 (41, 58) | 51 (43, 59) | 0.09 |
| Male | 92.7 | 87.7 | 0.17 |
| BMI (kg/m2) | 23.5 (21.1, 25.5) | 23.0 (20.6, 24.7) | 0.18 |
| Height (cm) | 170.0 (165.0, 172.0) | 169.0 (165.0, 172.0) | 0.17 |
| Weight (kg) | 67.5 (60.0, 74.0) | 65.0 (57.0, 70.0) | 0.09 |
| Diagnosis | 0.10 | ||
| HCC | 51.3 | 53.9 | |
| Hepatitis B virus-related | 19.3 | 22.8 | |
| cirrhosis | |||
| ACLF | 14.7 | 8.3 | |
| Alcoholic cirrhosis | 6.0 | 3.6 | |
| Other | 8.7 | 11.4 | |
| Comorbidity | |||
| Diabetes | 18.0 | 13.9 | 0.21 |
| Hypertension | 15.3 | 13.1 | 0.48 |
| Cardiovascular system | 4.0 | 3.4 | 0.73 |
| diseases | |||
| Pre-transplantation | |||
| Laboratory MELD score | 13 (7, 26) | 11 (6, 20) | 0.02 |
| CREA (μmol/L) | 72 (60, 93) | 71 (59, 88) | 0.94 |
| TBIL (μmol/L) | 58.1 (26.6, 352.4) | 39.5 (19.4, 178.2) | 0.01 |
| INR | 1.40 (1.18, 2.15) | 1.33 (1.11, 1.85) | 0.03 |
| Child-Pugh score | 9 (7, 10) | 8 (6, 10) | 0.34 |
| Infection | 9.3 | 10.8 | 0.60 |
| Renal replacement therapy | 0.7 | 1.5 | 0.99 |
| Mechanical ventilation | 0 | 1.3 | 0.52 |
| Donor | |||
| Age (Years) | 40 (26, 47) | 38 (23, 47) | 0.37 |
| Male | 74.7 | 75.0 | 0.94 |
| BMI (kg/m2) | 22.5 (20.5, 24.2) | 22.0 (20.3, 23.9) | 0.15 |
| Height (cm) | 168.0 (160.0, 170.0) | 168.0 (160.0, 170.0) | 0.82 |
| Weight (kg) | 62.5 (55.0, 70.0) | 60.0 (55.0, 67.0) | 0.17 |
| Cause of death | 0.63 | ||
| Trauma | 50.0 | 47.1 | |
| CVA | 34.0 | 38.1 | |
| HIE | 7.3 | 8.3 | |
| Others | 8.7 | 6.5 | |
| The Chinese Classification of Deceased Organ Donation | 0.18 | ||
| C-I (DBD) | 75.3 | 81.0 | |
| C-II (DCD) | 18.0 | 15.4 | |
| C-III (DBCD) | 6.7 | 3.6 | |
| Comorbidity | |||
| Hypertension | 12.2 | 9.5 | 0.34 |
| Diabetes | 8.8 | 9.5 | 0.79 |
| Cardiovascular system | 2.0 | 0.6 | 0.12 |
| diseases | |||
| Hepatic steatosis | |||
| DRI | 1.72 (1.45, 2.10) | 1.62 (1.41, 2.04) | 0.11 |
| Operation-related | |||
| Anhepatic phase (min) | 55 (45, 67) | 54 (43, 64) | 0.40 |
| CIT (min) | 458 (361, 565) | 407 (329, 508) | 0.001 |
| Total operation time | 475 (398, 540) | 445 (387, 510) | 0.06 |
| Transfusion | |||
| RBC (unit) | 4.3 (2.0, 9.0) | 5.0 (3.0, 8.0) | 0.40 |
| Fresh frozen plasma (unit) | 8.0 (5.0, 11.3) | 7.5 (5.0, 10.0) | 0.81 |
| Intraoperative hemorrhage (ml) | 1500 (800, 3000) | 1500 (1000, 2800) | 0.28 |
ACLF, acute-on-chronic liver failure; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CIT, cold ischemia time; CREA, creatinine; CVA, cerebrovascular accident; DBCD, donation after brain and cardiac death; DBD, donation after brain death; DCD, donation after cardiac death; DRI, donor risk index; HCC, hepatocellular carcinoma; HIE, hypoxic-ischemic encephalopathy; INR, international normalized ratio; MELD, Model for End-Stage Liver Disease; PLT, platelet; RBC, red blood cell; TBIL, total bilirubin.
Data for some variables were not available for some recipients or donors, so the results presented are based on available information only.