FIGURE 1.

Different high-resolution structures of Aβ, Tau, and α-Sn in the amyloid state. Top views are shown to highlight the two-fold symmetry arrangement of the protofilaments. Aβ: 2NAO, 5KK3, and 5OQV are synthetic Aβ₄₂ fibrils (syn); 6SHS are brain-derived Type II Aβ₄₀ fibrils from AD. Tau: 5O3L and 5O3T are respectively, ex vivo PHFs and SFs from AD; 6NWQ, 6TJX, 7P6C, 7P6E, and 7P67 are ex vivo Type II filaments from CTE, CBD, PSP, AGD, and GGT, respectively. α-Sn: 6A6B, 6CU7, and 6H6B are synthetic fibrils (syn); 6XYP are brain-derived Type I fibrils from MSA. Beta-sheets are depicted in blue and coils and α-helices in silver.