FIGURE 2.

Greek-key topology in the amyloid fold. Top views of the single chains of several amyloid structures of Aβ₄₂, Tau, and α-Sn are shown along with their associated disease or synthetic nature (syn). Synthetic HET prion (2RNM), human recombinant prion protein in the amyloid state (6LNI), infectious hamster brain-derived prion protein (7LNA), and mouse spleen-derived acute phase protein serum amyloid A1 (6DSO) are depicted for comparison. The enclosing red dotted lines highlight the Greek-key topology in each structure.