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. 2020 Sep 8;58(1):878–885. doi: 10.1080/13880209.2020.1806335

Figure 2.

Figure 2.

Fengbaisan treatment represses ERS and apoptosis by upregulating SIRT1 expression in A549 cells in vitro. A549 cells were treated with 10% CSE. Then, the CSE-induced A549 cells were treated with blank serum, serum containing Fengbaisan, serum containing Fengbaisan and DMSO or serum containing Fengbaisan and EX527. A549 cells did not receive special treatment as control. (A, B) WB was performed to assess the expression of SIRT1, TIMP-1, MMP-9, CHOP, GRP78, caspase-12 and caspase-3 in the A549 cells. (C) Flow cytometry was performed to examine the levels of apoptosis in the A549 cells. (**p < 0.01, vs. Ctrl; #p < 0.05, vs. blank serum; ##p < 0.01, vs. blank serum; $p < 0.05, vs. FBS serum + DMSO; $$p < 0.01, vs. FBS serum + DMSO).