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. 2020 Sep 8;58(1):878–885. doi: 10.1080/13880209.2020.1806335

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Fengbaisan treatment suppresses airway inflammation via SIRT1 pathway in lung tissues of COPD rats. Rats were challenged with CSE and LPS to construct rat model of COPD. COPD rats were treated with FBS, FBS + DMSO or FBS + EX527. Normal rats did not receive special treatment as control. (A) ELISA was performed to validate the levels of IL-1β, TNF-α and IL-8 in BALF of rats. (B) The total number of inflammatory cells in BALF of rats was counted using haemocytometer. (C) The percentage of neutrophils in BALF of rats was evaluated by Wright-Giemsa staining. (D) The pathological changes of lung tissues of rats were observed by HE staining. (**p < 0.01, vs. Normal; ^##p < 0.01, vs. Model; ^$$p < 0.01, vs. FBS + DMSO).