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. 2020 Sep 8;58(1):878–885. doi: 10.1080/13880209.2020.1806335

Figure 4.

Figure 4.

Fengbaisan treatment suppresses ERS and apoptosis by upregulating SIRT1 expression in lung tissues of COPD rats. Rats were challenged with CSE and LPS to construct rat model of COPD. COPD rats were treated with FBS, FBS + DMSO or FBS + EX527. Normal rats did not receive special treatment as control. (A, B) WB was performed to assess the expression of SIRT1, TIMP-1, MMP-9, CHOP, GRP78, caspase-12 and caspase-3 in lung tissues of COPD rats. (C) TUNEL staining was performed to examine the levels of apoptosis in lung tissues of COPD rats. (**p < 0.01, vs. Normal; ##p < 0.01, vs. Model; $$p < 0.01, vs. FBS + DMSO).