Figure 3.
Socheongryongtang prevented the LPS-induced morphological changes in the pulmonary system. (A) In H&E staining, socheongryongtang suppressed the morphological changes related to COPD, such as inflammatory cell infiltration near the small airway and airway wall destruction (emphysema). (B) In Masson’s trichrome staining, socheongryongtang decreased the fibrogenicity near the bronchoalveolar area. N = 6. Scale bar: 100 µm. (a) Control; (b) 0.8 mg/kg LPS intranasal instillation; (c) 1 mg/kg Spiriva treatment for five days after LPS instillation; (d) 150 mg/kg socheongryongtang treatment for five days after LPS instillation; (e) 1500 mg/kg socheongryongtang treatment for five days after LPS instillation. Arrow head, emphysema; arrow, fibrosis. Magnification, ×200.