Table 1.

Characteristics of the included studies.

References	Year	circRNAs profiles	Sample size (case/control)	Specimen source	Expression level	Reference gene	Sensitivity	Specificity	AUC
Hsiao et al. (19)	2017	has_circ_0001313	131/76	tissues	up-regulated	GAPDH	0.931	0.738	0.884
Sadeghi et al. (18)	2020	hsa_circ_0060927	83/83	tissues	up-regulated	GAPDH	0.68	0.83	0.78
Zhang et al. (24)	2018	hsa_circ_0007534	112/46	plasma	up-regulated	GAPDH	0.92	0.522	0.78
Li et al. (31)	2019	hsa_circ_0006990	60/43	plasma	up-regulated	GAPDH	0.7	0.651	0.724
Lin et al. (17)	2019	circ-CCDC66/circ-STIL /circ-ABCC1	45/61	plasma	up-regulated	GAPDH	0.644	0.852	0.78
Barbagallo et al. (20)	2018	hsa_circ_0000284	20/20	serum	up-regulated	GAPDH	0.71	0.8	0.771
Pan et al. (21)	2019	hsa-circ-0004771	110/35	serum	up-regulated	GAPDH	0.809	0.829	0.88
Xie et al. (16)	2020	circ-PNN	58/58	serum	up-regulated	GAPDH	0.897	0.69	0.826
Wang et al. (29)	2015	hsa_circ_001988	31/31	tissues	down-regulated	GAPDH	0.68	0.74	0.788
Zhuo et al. (27)	2017	hsa_circ_0003906	122/40	tissues	down-regulated	GAPDH	0.803	0.725	0.818
Zhang et al. (22)	2017	hsa_circ_103809	170/170	tissues	down-regulated	GAPDH	0.664	0.695	0.699
Zhang et al. (22)	2017	hsa_circ_104700	170/170	tissues	down-regulated	GAPDH	0.682	0.529	0.616
Wang et al. (23)	2018	hsa_circ_0014717	46/46	tissues	down-regulated	GAPDH	0.432	0.87	0.683
Wang et al. (30)	2018	hsa_circ_0000567	102/102	tissues	down-regulated	GAPDH	0.833	0.765	0.865
Li et al. (28)	2018	hsa_circ_0000711	101/101	tissues	down-regulated	GAPDH	0.91	0.58	0.81
Ji et al. (25)	2018	hsa_circ_0001649	64/64	tissues	down-regulated	GAPDH	0.828	0.781	0.857
Ruan et al. (32)	2019	hsa_circ_0002138	35/35	tissues	down-regulated	GAPDH	0.629	0.743	0.725
Ge et al. (26)	2019	hsa_circ_0142527	41/41	tissues	down-regulated	GAPDH	0.829	0.805	0.818