Effect of tissue plasminogen activator (tPA) on hypoxemia. Bars represent median (interquartile range [IQR]) values for the ratio of the partial pressure of arterial oxygen to fraction of inspired oxygen (PaO2:FiO2) before and after tPA receipt. “−1” represents the closest PaO2:FiO2 ratio obtained within 48 hours before tPA receipt. “+1,” “+2,” and “+3” represent the first three PaO2:FiO2 ratios obtained within 48 hours after tPA receipt. The median time from the “−1” PaO2:FiO2 ratio to tPA administration was 2.4 hours (IQR, 1.0–6.2). The median time from tPA administration to the “+1,” “+2,” and “+3” PaO2:FiO2 ratios was 3.0 (IQR, 1.3–9.1), 11.3 (IQR, 6.0–23.0), and 17.5 (IQR, 10.0–32.6) hours, respectively. The number of patients in the “All” category (n = 42) is less than 59 because 17 patients (28.8%) did not have arterial blood gas measurements obtained within 48 hours before and after tPA receipt.