Table 2.
Completed Clinical Trials Involving Testing of EPCs as a Transplantation Cellular Therapeutic for Various Conditions, as Reported by ClinicalTrials.gov
| Disease | Identifier Number | Cell Type Used | Outcome | Citation |
|---|---|---|---|---|
| Pulmonary | ||||
| Idiopathic pulmonary arterial hypertension | NCT00641836 | Autologous transplantation of circulating EPCs | Preliminary study showed feasibility and safety. Might have beneficial effects |
Wang et al., 2007 (142) |
| Idiopathic pulmonary arterial hypertension | NCT00551408 | Not reported | No study results found | N/A |
| Pulmonary hypertension | NCT00469027 | Transplantation of autologous eNOS-overexpressing EPCs | Tolerated by patients Evidence of short-term improvement associated with long-term benefits in function and quality of life |
Granton et al., 2015 (143) |
| NSCLC COPD |
NCT00826683 | Identification of circulating EPCs in peripheral blood of patients with NCSLC compared with patients with COPD | No study results found | N/A |
| Hepatic | ||||
| Advanced liver cirrhosis | NCT01333228 | Bone marrow–derived EPCs expanded ex vivo vWF+/acLDL+ |
No adverse effects observed Higher levels of VEGFR2, vWF, and acLDL showed greater improvement in liver function |
D’Avola et al., 2016 (150) |
| Cardiac | ||||
| Coronary artery disease Refractory angina |
NCT00694642 | CliniMACS selection of autologous CD133+ cells | No study results found | N/A |
| Idiopathic dilated cardiomyopathy | NCT00629096 | Intracoronary infusion of autologous bone marrow–derived MNCs | No study results found | N/A |
| Other | ||||
| Critical limb ischemia | NCT01595776 | CliniMACS selection of autologous CD133+ cells | Six of eight (75%) patients experienced complete wound healing Two of eight (25%) patients experienced no benefit |
Arici et al., 2015 (151) |
| Leg ulcer/gangrene | NCT00221143 | CliniMACS selection of autologous CD34+ cells from mobilized donors | Improvement in Wong-Baker FACES pain rating, TBPI, transcutaneous partial oxygen pressure, total or pain-free walking distance, and ulcer size observed in all patients | Kawamoto et al., 2009 (152) |
| Lymphedema (after mastectomy) | NCT01112189 | Transplantation of autologous CD34+ cells (unsorted) from buffy coat samples | Significantly reduced volume of Lymphedema and improved associated symptoms | Maldonado et al., 2011 (153) |
Definition of abbreviations: acLDL = Dil-labeled acetylated low-density lipoprotein; COPD = chronic obstructive pulmonary disease; MNCs = mononuclear cells; N/A = not applicable; NSCLC = non-small cell lung cancer; TBPI = toe brachial pressure index; VEGFR2 = vascular endothelial growth factor receptor 2; vWF = von Willebrand factor.