Fig. 6. C1qbp is required for the dynamic transcriptional program of effector CD8⁺ T cells.

(A and B) Volcano plots illustrating DEGs in the WT and C1qbp-deficient P14 CD8⁺ T cells from recipient mice at day 3 (A) and day 5 (B) after infection with the LCMV Armstrong strain (n = 2 per group). (C) GO analysis of DEGs in WT and C1qbp-deficient P14 CD8⁺ T cells as in (B). rRNA, ribosomal RNA. (D) GSEA of indicated signature genes from the ranked list of DEGs in WT versus C1qbp-deficient P14 CD8⁺ T cells as in (B). (E and F) Heatmaps of differentially expressed effector signature and memory signature genes in the WT and C1qbp-deficient CD8⁺ T cells from recipient mice at days 3 (E) and 5 (F) after infection with the LCMV Armstrong strain. (G to J) The ratio of sequence tags for H3K27Ac (G), H3K27me3 (H), CpG 5mC (I), and ATAC (J) correlated with the log₂ fold change in mRNA expression between WT and C1qbp-deficient CD8⁺ T cells as in (B).