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Organization of SARS-CoV-2. (a) Overall genomic organization of SARS-CoV-2. Non-structural proteins Nsp1-16 are expressed as polyproteins Pp1a and Pp1ab and are cleaved by internal Mpro and PLPro proteases. Structural proteins S, E, M, and N are encoded by their respective genes, interspaced with accessory proteins which include ORF3a. (b) A schematic model of SARS-CoV-2 virion with structural proteins indicated.
