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. 2022 Feb;52:123–134. doi: 10.1016/j.coviro.2021.11.011

Figure 3.

Figure 3

Structures of other viral components. (a) Top and side view of the transmembrane domain of SARS-CoV-2 E in lipid bilayers with hydrophobic residues in red (PDB 7K3G) [64•]. (b) Crystal structures of N NTD (green, PDB 7CDZ) [67] and CTD dimer (blue and orange, PDB 7CE0) [67] and 13.1 Å cryoET/STA density map of the RNP complex (grey, EMD-30429) [24••]. (c) Crystal structure of the SARS-CoV-2 Main Protease dimer (Mpro, left, PDB 6Y2E) [8•] and Papain-like Protease (PLpro, right, PDB 6WZU) [11]. The Mpro catalytic dyad His41 and Cys145 are shown in red and orange, respectively and the N-terminal finger of each protomer is shown in magenta. The PLpro ubiquitin-like domain is shown in brown and catalytic domain in rose. (d) CryoEM structure of Nsp1 bound within the mRNA entrance channel of 40S ribosome subunit, with a close-up surface representation of the ribosome showing Nsp1 helices within entrance channel (PDB 6ZOK) [77]. (e) Crystal structure of Nsp21-276 (light blue) (PDB 7EXM) [80]. (f) CryoEM structure of the Nsp3 macrodomain (blue) in complex with ADP-ribose (orange) (PDB 6W02) [82]. (g) CryoEM structure of the SARS-CoV-2 Nsp13-RTC complex with RNA (PDB 6XEZ) [88]. (h) CryoEM structure of the cap(0)-RTC complex consisting of Nsp9/10/14 bound to the Nsp13-RTC complex (PDB 7EIZ) [95••]. (i) Crystal structure of the Nsp16 (light yellow) and Nsp10 (dark blue) heterodimer with an RNA cap analog (cyan) and S-adenosyl methionine or SAM (red) with an occupied adenosine binding pocket (magenta) (PDB 6WKS) [98]. (j) Crystal structure of the Nsp15 hexameric endonuclease (PDB 6VWW) [99]. (k) CryoEM structure of ORF3a dimer in lipid nanodiscs. TM: Transmembrane domain. CD: Cytosolic Domain (PDB 6XDC and EMD-22136) [102]. (l) Crystal structure of ORF7a (pink) (PDB 7CI3) [103]. Disulfide bonds shown in green (m) Crystal structure of the ORF8 homodimer (tan and cyan) (PDB 7JTL) [104]. Disulfides conserved with ORF7a (green), intermolecular disulfide (yellow) and ORF8-specific disulfide (magenta) are shown. (n) CryoEM structure of ORF9b (red) bound to TOM70 (gold) (PDB 7KDT) [106].