Extended Data Fig. 4. Fc effector functions of WRAIR mAbs against SARS-CoV-2 IL1/2020.
a,Titrations of WRAIR NTD (blue) and RBD (red) mAbs in the Fc effector function assays. Antibodies are colored according to their competition groups. Fc effector functions were measured twice and shown are data from a single representative experiment. A Fc mutant control (LALA-PG) is shown for reference with open circle and dotted line. b, Correlation between neutralization activity and phagocytic activities for all mAbs. Spearman r and P (two-tailed) values are indicated above the graph, n = 31 xy pairs. c, Difference in ADNP score between NTD neutralizing and non-neutralizing mAbs. Black horizontal line indicates mean value and asterisks represent significance by two-tailed Mann–Whitney t-test, P = 0.0006, n = 7. Dotted line indicates positivity threshold.