Table 2.
Rapid screening tests to detect cognitive impairment in patients withmultiple sclerosis
| Test | |||
|---|---|---|---|
| Domain | PASAT [46, 47] | SDMT [48] | MSNQa [49] |
| Auditory processing speed and working memory | + | ||
| Visual processing speed and working memory | + | ||
| Information processing speed | + | ||
| Verbal learning | + | ||
| Mean score (standard deviation) | 46.7 (9.1)b50.4 (9.7)c | Depends on age and years of education | Not applicable |
| Duration | 10-15 minutes | 90 seconds(5 minutes including instructions) | Self-administered |
MSNQ: Multiple Sclerosis Neuropsychological Questionnaire; PASAT: Paced Auditory Serial Addition Test; SDMT: Symbol Digit Modalities Test
a MSNQ-Informant report correlates with Boston Naming Test (-0.45, p<0.001), CVLT-II Total Recall Trials 1-5 (-0.53, p<0.01), CVLT-II Delayed Recall (-0.43, p<0.001), BVMT-R Delayed Recall (-0.43, p<0.001), Trail Making Test (0.55, p<0.01), Paced Auditory Serial Addition (-0.47, p<0.001), WCST Perseveration Responses (0.37, p<0.01)
b Scores up to 12 years of education and c scores for 12 or more years of education, according to Rao et al (1991) [7]