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. 2021 Dec 3;10(12):84. doi: 10.1038/s41389-021-00374-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A CCT8 overexpressed lentivirus and three CCT8 siRNA were successfully constructed to study the effects of CCT8 in CRC cells. B The subcellular localization of CCT8 in CRC cells lines was assessed by immuno-fluorescence. C, D Representative figures of Transwell assays indicate the stimulatory role of CCT8 on CRC migration. Bars on the right panel represent the number of invaded cells (n = 3, P < 0.05). E, F Representative figures of the wound-sealing assays indicate that CCT8 could stimulate CRC cell migration. Bars on the right represent the migration distance of wound-healing assay (n = 3, P < 0.05). G, H Caeca orthotopic transplantation assay indicates the stimulatory role of CCT8 on hepatic metastasis (n = 5). The representative colon and liver samples are displayed and the HE staining of the representative tumors was placed on the middle panel, showing the boundaries between tumor and normal tissues. Bars of the right panel represented the volume of tumor in situ and number of metastatic nodules in liver respectively.