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. 2021 Dec 3;10(12):84. doi: 10.1038/s41389-021-00374-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The correlations between EMT transcription factors (snail, slug, and twist) and WTp53/MTp53. B GSEA demonstrated cell cycle and EMT transformation were closely related to the expression of CCT8. C The correlations between CCT8 and p53, cell cycle associated gene (CDK1, CDK4, CDK6, and CyclinD1) and EMT related markers (snail, slug, twist, N-cadherin, Vimentin, ZEB1 and α-SMA). D Effect of CCT8 on the expression of p53 were detected by Western Blotting analysis (a representative set of data was shown, n = 3). E, F Western Blot analysis was performed to detect the protein expression of cell cycle pathway and epithelial-mesenchymal transition (EMT).