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. 2021 Dec 3;10(12):84. doi: 10.1038/s41389-021-00374-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A CCT8 gene expression from TCGA CRC database. (p = 2.351e-18). B Kaplan-Meier survival curves and univariate analyses(log-rank) of CRC samples obtained from PrognoScan database with distinct expression level of CCT8.(p = 0.0425). C Western Blot analysis was performed to detect CCT8 protein expression in CRC tissues (T) and adjacent non-tumor tissues (N). RT-PCR was performed to detect the CCT8 mRNA expression in CRC tissues and adjacent non-tumor tissues. D The expression of CCT8 in CRC tissues and adjacent nontumor tissues. E Graphical illustration of statistical CCT8 distribution in CRC tissues. CCT8 was significantly higher in CRC than in adjacent nontumorous tissue. The high expression of CCT8 was more frequently found in CRC with lymph node metastasis than in CRC without lymph node metastasis (N0). The high expression of CCT8 was more frequently found in advanced CRC (Stage I < Stage II < Stage III).