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. 2021 Dec 3;7:85. doi: 10.1038/s41522-021-00256-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Heatmap illustrating genus-specific functions with significantly differential abundance between AL and TR groups (FDR < 0.1). A single or double asterisk refers to FDR < 0.01 or <0.001, respectively. Each dot indicates a different sample; the color gradient is based on the relative abundance of functions. Functions are ordered sequentially: (i) according to the group of rats in which they are significantly more abundant, indicated in the bottom; (ii) according to their COG category, indicated close to the left margin of the heatmap (C, Energy production and conversion; D, Cell cycle control, cell division, chromosome partitioning; E, Amino acid transport and metabolism; G, Carbohydrate transport and metabolism; I, Lipid transport and metabolism; J, Translation, ribosomal structure and biogenesis; L, Replication, recombination and repair; N, Cell motility; O, Posttranslational modification, protein turnover, chaperones; V, Defense mechanisms); (iii) according to the taxonomic genus to which they were assigned, indicated close to the right margin of the heatmap; (iv) in alphabetical order.