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THZ531 (A) inhibition of CDK12/13 is time dependent. In vitro kinase activity assay of CDK12-cyclin K (B) and CDK13-cyclin K (C) with different concentrations of THZ531 and varying preincubation times. For all incubation time series, the counts per minute of the kinase activity measurements were normalized to the relative 32P transfer. (B) and (C) Adapted with modification from Ref. 96. Copyright ©2016 Springer Nature.
