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. 2021 Mar 13;11(11):3553–3566. doi: 10.1016/j.apsb.2021.03.021

Figure 1.

Figure 1

PCA protects the heart from ISO challenge in rats. The levels of circulating (A) CK-MB and (B) LDH in the plasma (n = 6). (C) The ratio of heart weight to tibia length (HW/TL) (n = 6). (D) One of representative H&E stained heart sections and cardiomyocyte cross-sectional area (n = 6, scale bar = 50 μm). 4-HNE (E) and 8-OHDG (F) content in the heart (n = 6). (G) Immunocytochemical staining of BAX, BCL-2 and c-caspase 3 protein expression (one of 6 independent experiments; scale bar = 50 μm). (H) Representative TUNEL staining images and quantification of TUNEL positive cells (n = 6). Cell survival of primary neonatal rat ventricular myocytes (NRVMs) when exposed to 1% O2 in glucose-free DMEM (OGD) for 6 h (I) or H2O2 for 8 h (J) (n = 6). (K) Intracellular ROS production in NRVMs exposed to OGD for 4 h (n = 6). Results are shown as mean ± SD; ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001.