Figure 1.

High fat diet intake and leptin receptor deficient obesity-modulated molecular events and cell signaling pathways in livers. Liver tissues of rats fed high fat diet for 20 weeks (a–d) or db/db obese and C57BL/6J lean mice (e–h) were subjected to RNAseq analysis. (a and e) Heatmap displays significantly regulated genes in signaling pathways of PI3K–Akt, AMPK, and FoxO, as well as cellular processes of autophagy and mitophagy in rat (a) and mice (e), respectively. (b and f) GO analysis was conducted with all altered genes, and 20 highest-ranking biological process terms are shown, rat (b) and mice (f), respectively; (c and g) KEGG pathway analyses of all significantly regulated genes were performed, and the enrichment for cellular process of KEGG pathway is shown using bubble plot, rat (c) and mice (g), respectively; (d and h) Bubble plot shows the enrichment for signal transduction of KEGG pathway, rat (d) and mice (h), respectively.