Figure 2.

Biological process, molecular events, and cell signaling pathways in livers from lean and obese human liver samples were analyzed using label-free quantitative proteomics and LC–MS/MS to identify differentially expressed proteins. (a) Heatmap displays significantly regulated proteins in signaling pathways of PI3K–Akt, AMPK, and FoxO, as well as cellular processes of autophagy and mitophagy. (b) GO analysis was conducted with all altered proteins, and 20 highest-ranking biological process terms are shown. (c) KEGG pathway analyses of all significantly regulated proteins were performed, and the enrichment for cellular process of KEGG pathway is shown using bubble plot. (d) Bubble plot displays the enrichment for signal transduction of KEGG pathway.