Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 3;12:7051. doi: 10.1038/s41467-021-27242-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a Tested hypothesis. b Test for whether interactions change between cancer type A (detected; FDR 10%) and other cancers in which the gene is significantly mutated (compared). Ga Mut denotes the number of samples with somatic mutation of gene A in cancer type with a significant interaction, Ga CNAs indicates a number of samples with CNAs of gene A in cancer type with a significant interaction, and Tissue denotes the number of samples with genomic alterations of gene A in other significantly mutated cancer types. c Volcano plot comparing differences of the log of the odds ratios for the co-occurrences between mutation and CNA in two cancer types (i.e., detected cancer type and other significantly mutated cancer types together). A total of 48 detected interactions for 26 genes were tested. Color coding is for the cancer type in which the two-way interaction was detected (FDR = 10%). 0.5 was added to each frequency when calculating odds ratios to avoid division by zero frequencies. d Effect sizes (interaction coefficients) and FDR values for tissue-specific interactions were estimated as the ratio between the number of detected interactions in the permutated matrix and the number of detected with the real data with 100 permutations. Source data underlying c and d are provided as a Source Data file.