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. 2021 Dec 3;4:1357. doi: 10.1038/s42003-021-02883-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Metabolic pathway with significant enhancement by CSE treatment (a). The heatmaps on the left show that the relative abundance of several metabolic pathways was altered. Statistical analysis of the differences between the groups was performed using the original false discovery rate method of Benjamini and Hochberg. In the image, red represents increased relative abundance, blue represents decreased relative abundance, and * represents Q < 0.0001. The corresponding genus information is on the right. Effects of CSE on the primary bile acid biosynthesis pathway (b).