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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Curr Opin Genet Dev. 2021 Jun 5;71:1–9. doi: 10.1016/j.gde.2021.05.006

Figure 1.

Figure 1

(a) Initial events of DSB response signaling on chromatin. Loop extrusion promotes bidirectional spreading of ATM-catalyzed γH2AI marks within the boundary elements. (b) Recognition of H4K20me0 by BARD1-BRCA 1 complex on the nascent nucleosome precludes 53BP1 binding at DSBs. (c) Transcriptionally active chromatin preferentially gets repaired by BRCA-dependent HR.